One month’s worth of antibiotics was exhausted in less than 48 hours last week.
It comes as the demand for antibiotics to treat Group A Streptococcus infections remains at an “exceptional level”, according to the Department of Health.
It says demand is well in excess of what is usual for this time of year.
However, the system has been working hard to replenish stocks, and wholesalers are still receiving and making deliveries, with more scheduled over the coming days.
Wholesalers are carefully managing the volumes available to them to ensure that supplies are available to those in greatest need.
The increase in demand for antibiotics is being seen across the UK.
Locally community pharmacies, wholesalers and procurement teams have been working tirelessly to secure stock deliveries into Northern Ireland.