Around £180,000 worth of suspected cocaine was seized after a van was stopped near Hillsborough on Friday (November 8).
The van was stopped by police on the A1 carriageway and the suspected cocaine was discovered inside the van.
Following the discovery, police conducted a number of searches at six properties in the North and West Belfast, Lisburn and Crumlin areas on Tuesday.
Two men, aged 26 and 34, have been arrested on suspicion of drugs supply offences following the searches led by detectives.
The suspects are currently being interviewed in Musgrave Custody Suite.
Detective Sergeant Mo Kelly said this seizure and the subsequent arrests are further evidence of the police’s ongoing commitment to disrupting organised crime gangs who seek to profit from supplying illegal drugs within the community.
“This substantial seizure means that these suspected drugs have been removed from circulation and therefore cannot cause harm in local communities.
“Drugs ruin lives and line the pockets of organised criminals. We are determined to disrupt their activity and anyone involved in the drugs trade, or anyone tempted to become involved should be under no illusion – we will seek to identify them, arrest them and place them before the courts,” said Detective Sergeant Mo Kelly.
“I would appeal to anyone who has any information to call police on the non-emergency number 101. Alternatively, information can also be provided to the independent charity Crimestoppers on 0800 555 111, which is 100% anonymous and gives people the power to speak up and stop crime.”